The Perrin Technique

Dr Perrin's Theory

The Perrin Technique™ is based on Dr Perrin’s theory that different stress factors whether physical, allergies, emotional or infections lead to an overstrain of the sympathetic nervous system. Further investigation has led to a probable cause of this nervous system overload being a build up of toxins in the fluid around the brain and the spinal cord. Some of the poisons caused by infection or inflammation in the head or spine flow through  channels from the brain   into the lymph ducts of the head face and neck. The toxins are also meant to drain down the spinal cord and out into the lymph ducts lying along the spine. In a CFS/ME sufferer  there is a back flow of these normal drainage points which leads to further toxicity and dysfunction of the central nervous system. This leads to all the many symptoms we see in CFS/ME.

Research  over past 30 years has validated Dr Perrin’s theories.

The Perrin Technique™ is a manual method that aids the diagnosis and treatment of Chronic Fatigue Syndrome /Myalgic Encephalomyelitis CFS/ME and was developed in 1989 by British osteopath and neuroscientist Dr Raymond Perrin DO PhD.

CFS/ME according to Dr Perrin is caused by an accumulation of inflammatory chemicals and other toxic substances in the brain and spinal cord leading to a dysfunction of the sympathetic nervous system, part of the autonomic nervous system of the body, which deals with all the automatic functions of the body. Although it is known for being the system which helps us in times of danger and stress, often referred to as the ‘Fight or Flight’ system, the sympathetic nervous system is important in controlling blood flow and the normal functioning of all the organs of the body such as the heart, kidney, the bowel. We know it is vital for healthy lymphatic drainage. In CFS/ME sufferers the sympathetic nervous system will have been placed under stress for many years before the onset of the signs and symptoms. This stress may be of a physical nature due to postural strain or an old injury, it may be emotional, environmental such as pollution, or it may be due to stress on the immune system due to infection or allergy.

Dr Perrin hypothesised that one final trigger factor, usually a viral infection, leads to a breakdown of the sympathetic nervous system’s control of the lymphatic drainage leading to a reversal of flow of toxins towards the brain and the spinal cord. This produces further dysfunction of the central nervous system causing further backflow of toxins and further disruption of normal bodily functions and the disease that we know as CFS/ME. However, the final trigger may not be an infection but a physical, emotional or chemical trauma. The amount and type of toxicity is different in every patient and with over 100 Billion neurones (nerve cells) in the brain, it isn’t any wonder that every CFS/ME patient have a different presentation and many combinations of symptoms which adds further confusion in the medical world.

The connection between the lymphatic system and the brain was only discovered to exist in humans in 2017 so the scientific basis of The Perrin Technique that CFS/ME was due to a disturbed neuro-lymphatic system was almost 30 years ahead of its time and initially opposed by most scientists and medics around the world. Now we know differently, with the neuro-lymphatic (also known as the Glymphatic) system being a proven mechanism that drains large molecules and poisons via cerebrospinal fluid into lymphatic vessels lining the brain.

Some of the toxins caused by infection or inflammation in the head or spine should flow through perforations in a bony plate (the cribriform plate) just above the nasal cavity plus through other cranial nerve pathways such as the optic and auditory pathways and the trigeminal into the lymph ducts around the eyes, ears and mouth and down the face and neck. The toxins are also meant to drain down the spinal cord and out into the lymph ducts lying along the spine. Dr Perrin has discovered that the common finding in CFS/ME patients is that these normal drainage points are structurally damaged by prior trauma to the head and spine or developmental or congenital and hereditary problems that lead to structural disturbances in these important areas. The damage may seem quite minor but it can lead to a restriction of healthy drainage leading to congestion in the neurolymphatic flow that starts the vicious cycle of neurotoxicity that leads to the reversal of lymphatic flow also leading to engorged ‘varicose’ lymphatic vessels found especially in the chest and neck.


Further investigation has shown that the reversal of the neurolymphatic flow and the disturbed sympathetic nervous system has led to other common physical signs that are found in CFS/ME patients.
CFS/ME is very much a biomechanical disorder with clear and diagnosable physical signs, including disturbed spinal posture, varicose enlarged lymph vessels and specific tender points related to sympathetic nerve disturbance and backflow of lymphatic fluid. The fluid drainage from the brain to the lymphatics moves in a rhythm that can be palpated using cranial osteopathic techniques. A trained practitioner can feel a disturbance of the cranial rhythm in CFS/ME.
By identifying the common signs in all CFS/ME sufferers, Dr Perrin has devised a physical examination that results in an aid to a definitive diagnosis. The diagnostic signs of The Perrin Technique™ have been tested and supported by the rigor of an NHS controlled trial, published in the British Medical Journal (BMJ Open) in November 2017.


The Perrin Technique™ treatment manually stimulates the fluid motion around the brain and spinal cord by a combination of specific adapted osteopathic techniques and manual lymphatic drainage developed by Dr. Raymond Perrin which aids drainage of these toxins out of the cerebrospinal fluid.

Cranial and spinal techniques together with the massage of the soft tissues in the head, neck, back and chest together with the gentle stroking lymphatic techniques direct all the toxins out of the lymphatic system and into the blood, where they are eventually detoxified in the liver.

Eventually with no poisons affecting the brain, the sympathetic nervous system begins to function correctly, and providing the patients pace and do not overstrain themselves their symptoms should gradually improve and in time some patients become totally symptom free.


An adapted form of The Perrin Technique™ is also helpful in the treatment of Fibromyalgia Syndrome (FMS) which is often diagnosed with patients who have CFS/ME. Dr. Perrin believes FMS is caused by the same biomechanical problems as CFS/ME with the toxins in these patients targeting the pain control centres in the brain leading to widespread severe myalgia (muscle pain) in all parts of the body and many of the symptoms of ME.

To see patients return to their normal healthy lives see the film ‘The Perrin Technique‘.

"I was well, within weeks, after twelve years of a miserable life. It is incredible to me even now when I think about it."
Elizabeth Smith
Toronto, Canada
"Treatments have proved highly effective in mitigating the severe symptoms endured by our daughter. We are convinced in Dr Perrin treatment."
Mr & Mrs A
"Dr Perrin's treatment alleviates my symptoms and gives me the boost I need to live a more or less normal life."
Mrs J C
"I would have absolutely no hesitation in recommending Dr Perrin and his work to and ME/Chronic Fatigue Syndrome sufferer."
Mrs L W