A paper published in International Journal of Molecular Sciences on 27 November 2025 explores “Glymphatic System Dysregulation as a Key Contributor to ME/CFS” – something Dr Perrin first proposed over 35 years ago!
We believe the ME/CFS medical / scientific community will be interested in seriously considering glymphatic dysfunction an important contributor to its pathophysiology. If so, therapeutics that modulate glymphatic function may also benefit patients with ME/CFS.
– Int. J. Mol. Sci. 2025, 26(23), 11524;
https://doi.org/10.3390/ijms262311524
While the paper does not reference Dr Perrin’s pioneering work, it is another strong sign that the wider scientific community is continuing to validate the fundamentals of the Perrin Technique™.